[HTML][HTML] Regulation of human vascular endothelial growth factor mRNA stability in hypoxia by heterogeneous nuclear ribonucleoprotein L
SC Shih, KP Claffey - Journal of Biological Chemistry, 1999 - ASBMB
A 126-base region of human vascular endothelial growth factor (VEGF) 3′-untranslated
region, which we identified as the hypoxia stability region, forms seven hypoxia-inducible
RNA-protein complexes with apparent molecular masses ranging from 40 to 90 kDa in RNA-
UV-cross-linking assays. In this study, we show that proteins that form the 60-kDa RNA-
protein complex with the hypoxia stability region were present in both cytoplasmic and
nuclear compartments. We purified the protein associated in the 60-kDa complex and …
region, which we identified as the hypoxia stability region, forms seven hypoxia-inducible
RNA-protein complexes with apparent molecular masses ranging from 40 to 90 kDa in RNA-
UV-cross-linking assays. In this study, we show that proteins that form the 60-kDa RNA-
protein complex with the hypoxia stability region were present in both cytoplasmic and
nuclear compartments. We purified the protein associated in the 60-kDa complex and …