RAS in cellular transformation and senescence
GM DeNicola, DA Tuveson - European journal of cancer, 2009 - ejcancer.com
In 1964, a transforming retrovirus was described that produced tumours in mice [1]. The
Harvey rat sarcoma virus, aptly named H-RAS after the discovering scientist, encoded an
oncogene that had been hijacked from its host. A similar virus was isolated in 1970 and was
named the Kirsten rat sarcoma virus or K-RAS [2]. In 1982, the human genes homologous to
the viral genes were elucidated and were designated cH-RAS and cK-RAS [3], and
subsequently the third and final RAS family member was isolated from human …
Harvey rat sarcoma virus, aptly named H-RAS after the discovering scientist, encoded an
oncogene that had been hijacked from its host. A similar virus was isolated in 1970 and was
named the Kirsten rat sarcoma virus or K-RAS [2]. In 1982, the human genes homologous to
the viral genes were elucidated and were designated cH-RAS and cK-RAS [3], and
subsequently the third and final RAS family member was isolated from human …