[HTML][HTML] BNIP3 heterodimerizes with Bcl-2/Bcl-XL and induces cell death independent of a Bcl-2 homology 3 (BH3) domain at both mitochondrial and …
R Ray, G Chen, CV Velde, J Cizeau, JH Park… - Journal of Biological …, 2000 - ASBMB
BNIP3 (formerly NIP3) is a pro-apoptotic, mitochondrial protein classified in the Bcl-2 family
based on limited sequence homology to the Bcl-2 homology 3 (BH3) domain and COOH-
terminal transmembrane (TM) domain. BNIP3 expressed in yeast and mammalian cells
interacts with survival promoting proteins Bcl-2, Bcl-X L, and CED-9. Typically, the BH3
domain of pro-apoptotic Bcl-2 homologues mediates Bcl-2/Bcl-X L heterodimerization and
confers pro-apoptotic activity. Deletion mapping of BNIP3 excluded its BH3-like domain and …
based on limited sequence homology to the Bcl-2 homology 3 (BH3) domain and COOH-
terminal transmembrane (TM) domain. BNIP3 expressed in yeast and mammalian cells
interacts with survival promoting proteins Bcl-2, Bcl-X L, and CED-9. Typically, the BH3
domain of pro-apoptotic Bcl-2 homologues mediates Bcl-2/Bcl-X L heterodimerization and
confers pro-apoptotic activity. Deletion mapping of BNIP3 excluded its BH3-like domain and …