[HTML][HTML] Functional interaction of p53 and BLM DNA helicase in apoptosis
The Bloom syndrome (BS) protein, BLM, is a member of the RecQ DNA helicase family that
also includes the Werner syndrome protein, WRN. Inherited mutations in these proteins are
associated with cancer predisposition of these patients. We recently discovered that cells
from Werner syndrome patients displayed a deficiency in p53-mediated apoptosis and WRN
binds to p53. Here, we report that analogous to WRN, BLM also binds to p53 in vivo andin
vitro, and the C-terminal domain of p53 is responsible for the interaction. p53-mediated …
also includes the Werner syndrome protein, WRN. Inherited mutations in these proteins are
associated with cancer predisposition of these patients. We recently discovered that cells
from Werner syndrome patients displayed a deficiency in p53-mediated apoptosis and WRN
binds to p53. Here, we report that analogous to WRN, BLM also binds to p53 in vivo andin
vitro, and the C-terminal domain of p53 is responsible for the interaction. p53-mediated …