A platelet membrane protein expressed during platelet activation and secretion. Studies using a monoclonal antibody specific for thrombin-activated platelets.
SC Hsu-Lin, CL Berman, BC Furie, D August… - Journal of Biological …, 1984 - ASBMB
To identify structures on the platelet surface which become expressed after platelet
activation, we have prepared murine monoclonal antibodies specific for thrombin-activated
platelets. Hybridomas were screened for clones producing antibodies which bound to
thrombin-activated platelets but not to resting platelets. Clone KC4 was identified. The
binding of purified I-labeled KC4 antibody, an IgG1k, to thrombin-activated platelets was
saturable. Minimal binding was observed to resting platelets. The interaction of antibody with …
activation, we have prepared murine monoclonal antibodies specific for thrombin-activated
platelets. Hybridomas were screened for clones producing antibodies which bound to
thrombin-activated platelets but not to resting platelets. Clone KC4 was identified. The
binding of purified I-labeled KC4 antibody, an IgG1k, to thrombin-activated platelets was
saturable. Minimal binding was observed to resting platelets. The interaction of antibody with …