PD-1 expression on human CD8 T cells depends on both state of differentiation and activation status
D Sauce, JR Almeida, M Larsen, L Haro, B Autran… - Aids, 2007 - journals.lww.com
D Sauce, JR Almeida, M Larsen, L Haro, B Autran, GJ Freeman, V Appay
Aids, 2007•journals.lww.comObjective and design: PD-1 expression on HIV-specific CD8 T cells was recently reported to
reflect functional exhaustion, resulting in uncontrolled HIV-1 replication. Assessing PD-1
expression on T cells may be highly relevant in T-cell immunology and vaccine monitoring.
However, this requires us to gain further insights into the significance of PD-1 expression on
CD8 T cells in humans. Methods: We performed a detailed analysis of PD-1 expression
pattern on various CD8 T cell subsets from healthy or HIV infected donors. Results: PD-1 …
reflect functional exhaustion, resulting in uncontrolled HIV-1 replication. Assessing PD-1
expression on T cells may be highly relevant in T-cell immunology and vaccine monitoring.
However, this requires us to gain further insights into the significance of PD-1 expression on
CD8 T cells in humans. Methods: We performed a detailed analysis of PD-1 expression
pattern on various CD8 T cell subsets from healthy or HIV infected donors. Results: PD-1 …
Abstract
Objective and design:
PD-1 expression on HIV-specific CD8 T cells was recently reported to reflect functional exhaustion, resulting in uncontrolled HIV-1 replication. Assessing PD-1 expression on T cells may be highly relevant in T-cell immunology and vaccine monitoring. However, this requires us to gain further insights into the significance of PD-1 expression on CD8 T cells in humans.
Methods:
We performed a detailed analysis of PD-1 expression pattern on various CD8 T cell subsets from healthy or HIV infected donors.
Results:
PD-1 expression has two facets in vivo. On the one hand, it is linked to T-cell differentiation: PD-1 is up-regulated on early/intermediate differentiated subsets, which include HIV and Epstein–Barr virus-specific CD8 T-cell populations, but is down-regulated during late stages of differentiation. On the other hand, it is linked to T-cell activation: on PD-1 positive cells, PD-1 over-expression occurs along with the up-regulation of activation markers such as CD38 or HLA-DR.
Conclusions:
PD-1 expression on CD8 T cells, including those specific for HIV, can be related both to their differentiation stage and their activation status. It is important to consider these findings when assessing the expression of PD-1 on T cells.
Lippincott Williams & Wilkins