[HTML][HTML] Low pre-infection levels and loss of central memory CD4+ T cells may predict rapid progression in SIV-infected pigtail macaques

RD Mason, R De Rose, N Seddiki, AD Kelleher… - Virology, 2008 - Elsevier
RD Mason, R De Rose, N Seddiki, AD Kelleher, SJ Kent
Virology, 2008Elsevier
CD4+ T lymphocyte subsets are targeted to different degrees by SIV infection. We studied
central memory, effector memory, naïve, and regulatory T cell levels longitudinally in 11
SIVmac251-infected pigtail macaques. Depletion of CD28+ CD95+ central memory CD4+ T
cells, but not other populations, correlated with both SIV viral load and disease progression.
A low pre-infection level of central memory CD4+ T cells was also predictive of rapid disease
progression. If confirmed in larger studies, our results suggest stratifying macaques for …
CD4+ T lymphocyte subsets are targeted to different degrees by SIV infection. We studied central memory, effector memory, naïve, and regulatory T cell levels longitudinally in 11 SIVmac251-infected pigtail macaques. Depletion of CD28+CD95+ central memory CD4+ T cells, but not other populations, correlated with both SIV viral load and disease progression. A low pre-infection level of central memory CD4+ T cells was also predictive of rapid disease progression. If confirmed in larger studies, our results suggest stratifying macaques for baseline central memory CD4+ T cells would be useful in defining both the pathogenesis of SIV disease and SIV vaccine efficacy.
Elsevier