[HTML][HTML] Phosphatidylinositol 3-Kinase, but Not p70/p85 Ribosomal S6 Protein Kinase, Is Required for the Regulation of Phosphoenolpyruvate Carboxykinase …
C Sutherland, RM O'Brien, DK Granner - Journal of Biological Chemistry, 1995 - ASBMB
Phosphoenolpyruvate carboxykinase (PEPCK) catalyzes the rate-limiting step in hepatic
gluconeogenesis. Glucagon (via the second messenger cAMP) and glucocorticoids
stimulate the transcription of the PEPCK gene, whereas insulin and phorbol esters inhibit, in
a dominant fashion, these effects. Wortmannin, an inhibitor of phosphatidylinositol 3-kinase,
prevents the stimulation of glycogen synthesis, glucose transport, mitogen-activated protein
kinase, and p70/p85 ribosomal S6 protein kinase by insulin. We now show that wortmannin …
gluconeogenesis. Glucagon (via the second messenger cAMP) and glucocorticoids
stimulate the transcription of the PEPCK gene, whereas insulin and phorbol esters inhibit, in
a dominant fashion, these effects. Wortmannin, an inhibitor of phosphatidylinositol 3-kinase,
prevents the stimulation of glycogen synthesis, glucose transport, mitogen-activated protein
kinase, and p70/p85 ribosomal S6 protein kinase by insulin. We now show that wortmannin …