[HTML][HTML] Dual specificity MAPK phosphatase 3 activates PEPCK gene transcription and increases gluconeogenesis in rat hepatoma cells
H Xu, Q Yang, M Shen, X Huang, M Dembski… - Journal of Biological …, 2005 - ASBMB
Insulin is a key hormone that controls glucose homeostasis. In liver, insulin suppresses
gluconeogenesis by inhibiting the transcriptions of phosphoenolpyruvate carboxylase
(PEPCK) and glucose-6-phosphatase (G6Pase) genes. In insulin resistance and type II
diabetes there is an elevation of hepatic gluconeogenesis, which contributes to
hyperglycemia. To search for novel genes that negatively regulate insulin signaling in
controlling metabolic pathways, we screened a cDNA library derived from the white adipose …
gluconeogenesis by inhibiting the transcriptions of phosphoenolpyruvate carboxylase
(PEPCK) and glucose-6-phosphatase (G6Pase) genes. In insulin resistance and type II
diabetes there is an elevation of hepatic gluconeogenesis, which contributes to
hyperglycemia. To search for novel genes that negatively regulate insulin signaling in
controlling metabolic pathways, we screened a cDNA library derived from the white adipose …