[HTML][HTML] Unraveling the story of NGF-mediated sensitization of nociceptive sensory neurons: ON or OFF the Trks?
GD Nicol, MR Vasko - Molecular interventions, 2007 - triggered.clockss.org
Abstract Nerve Growth Factor (NGF) is produced by and affects a number of immune and
inflammatory cells. As part of the inflammatory response, NGF directly or indirectly alters the
sensitivity of small diameter sensory neurons that communicate noxious information. The
question remains as to the receptors and intracellular signaling cascades that mediate this
sensitizing action of NGF. Although the general consensus is that NGF produces peripheral
sensitization by activating TrkA, recent work suggests that p75 also contributes. Thus, both …
inflammatory cells. As part of the inflammatory response, NGF directly or indirectly alters the
sensitivity of small diameter sensory neurons that communicate noxious information. The
question remains as to the receptors and intracellular signaling cascades that mediate this
sensitizing action of NGF. Although the general consensus is that NGF produces peripheral
sensitization by activating TrkA, recent work suggests that p75 also contributes. Thus, both …