Differential spinal cord gene expression in rodent models of radicular and neuropathic pain
ML LaCroix-Fralish, VL Tawfik, FY Tanga… - The Journal of the …, 2006 - pubs.asahq.org
Background Neuropathic pain and radicular low back pain both have a major impact on
human health worldwide. Microarray gene analysis on central nervous system tissues holds
great promise for discovering novel targets for persistent pain modulation. Methods Rat
models of lumbar radiculopathy (L5 nerve root ligation) and neuropathy (L5 spinal nerve
transection) were used for these studies. The authors measured mechanical allodynia
followed by analysis of global gene expression in the lumbar spinal cord at two time points …
human health worldwide. Microarray gene analysis on central nervous system tissues holds
great promise for discovering novel targets for persistent pain modulation. Methods Rat
models of lumbar radiculopathy (L5 nerve root ligation) and neuropathy (L5 spinal nerve
transection) were used for these studies. The authors measured mechanical allodynia
followed by analysis of global gene expression in the lumbar spinal cord at two time points …