Effects of functional knock-out of α1 glycine-receptors on breathing movements in oscillator mice

U Markstahler, E Kremer, S Kimmina, K Becker… - Respiratory physiology …, 2002 - Elsevier
The effects of a deficiency of glycinergic inhibition deriving from mutations of the glycine-
receptor gene Glra1 on the breathing pattern of oscillator mice were studied. We compared
the development of breathing frequency, tidal volume and minute ventilation from control
mice (wild type-and heterozygous oscillator mice) with those of homozygous oscillator mice
during early postnatal periods from p9 until p21. The changes of ventilation were correlated
with body-weight and changes in blood-pH. During the second to third weeks of postnatal …