Extracellular activities of human granzymes: I. granzyme A induces IL6 and IL8 production in fibroblast and epithelial cell lines
LE Sower, GR Klimpel, W Hanna, CJ Froelich - Cellular immunology, 1996 - Elsevier
Situated in secretory granules of cytotoxic cells, granzymes are essential for induction of
target cell apoptosis with perforin. However, since cytotoxic cells constitutively secrete a
portion of their synthesized granzymes, these proteases could mediate extracellular
functions independently of their role in the lytic event. Thrombin has been shown to function
as an activation molecule by cleaving its receptor. We hypothesize that granzymes may act
similarly. In this report, we show that purified human granzyme A can induce human lung …
target cell apoptosis with perforin. However, since cytotoxic cells constitutively secrete a
portion of their synthesized granzymes, these proteases could mediate extracellular
functions independently of their role in the lytic event. Thrombin has been shown to function
as an activation molecule by cleaving its receptor. We hypothesize that granzymes may act
similarly. In this report, we show that purified human granzyme A can induce human lung …