[HTML][HTML] Liver-specific Deletion of the Growth Hormone Receptor Reveals Essential Role of Growth Hormone Signaling in Hepatic Lipid Metabolism*♦
Growth hormone (GH) plays a pivotal role in growth and metabolism, with growth promotion
mostly attributed to generation of insulin-like growth factor I (IGF-I) in liver or at local sites of
GH action, whereas the metabolic effects of GH are considered to be intrinsic to GH itself. To
distinguish the effects of GH from those of IGF-I, we developed a Cre-lox-mediated model of
tissue-specific deletion of the growth hormone receptor (GHR). Near total deletion of the
GHR in liver (GHRLD) had no effect on total body or bone linear growth despite a> 90 …
mostly attributed to generation of insulin-like growth factor I (IGF-I) in liver or at local sites of
GH action, whereas the metabolic effects of GH are considered to be intrinsic to GH itself. To
distinguish the effects of GH from those of IGF-I, we developed a Cre-lox-mediated model of
tissue-specific deletion of the growth hormone receptor (GHR). Near total deletion of the
GHR in liver (GHRLD) had no effect on total body or bone linear growth despite a> 90 …