Association of genetic variants of the chemokine receptor CCR5 and its ligands, RANTES and MCP–2, with outcome of HCV infection
The effect of host genetic variation on the outcome of hepatitis C virus (HCV) infection and its
treatment is poorly understood. The chemokine receptors CCR5, CCR2, and CCR3 and
their ligands, RANTES, MCP–1, MCP–2, and MIP–1α, are involved in the immune
responses and the selective recruitment of lymphocytes to the liver in HCV infection. We
studied 20 polymorphisms within these genes and investigated their association with
persistent carriage of HCV, severity of liver disease, hepatic inflammation, and response to …
treatment is poorly understood. The chemokine receptors CCR5, CCR2, and CCR3 and
their ligands, RANTES, MCP–1, MCP–2, and MIP–1α, are involved in the immune
responses and the selective recruitment of lymphocytes to the liver in HCV infection. We
studied 20 polymorphisms within these genes and investigated their association with
persistent carriage of HCV, severity of liver disease, hepatic inflammation, and response to …