RANTES: a versatile and controversial chemokine
V Appay, SL Rowland-Jones - Trends in immunology, 2001 - cell.com
V Appay, SL Rowland-Jones
Trends in immunology, 2001•cell.comThe activity of the chemokine RANTES is not restricted merely to chemotaxis. It is a powerful
leukocyte activator, a feature potentially relevant in a range of inflammatory disorders.
RANTES has attracted attention because it can potently suppress and, in some
circumstances, enhance HIV replication. These characteristics are critically dependent on its
ability to self-aggregate and bind to glycosaminoglycans.
leukocyte activator, a feature potentially relevant in a range of inflammatory disorders.
RANTES has attracted attention because it can potently suppress and, in some
circumstances, enhance HIV replication. These characteristics are critically dependent on its
ability to self-aggregate and bind to glycosaminoglycans.
Abstract
The activity of the chemokine RANTES is not restricted merely to chemotaxis. It is a powerful leukocyte activator, a feature potentially relevant in a range of inflammatory disorders. RANTES has attracted attention because it can potently suppress and, in some circumstances, enhance HIV replication. These characteristics are critically dependent on its ability to self-aggregate and bind to glycosaminoglycans.
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