5-HT7 receptor activation inhibits mechanical hypersensitivity secondary to capsaicin sensitization in mice
A Brenchat, L Romero, M García, M Pujol, J Burgueño… - PAIN®, 2009 - Elsevier
This work aimed to evaluate the potential role of the 5-HT7 receptor in nociception
secondary to a sensitizing stimulus in mice. For this purpose, the effects of relevant ligands
(5-HT7 receptor agonists: AS-19, MSD-5a, E-55888; 5-HT7 receptor antagonists: SB-
258719, SB-269970; 5-HT1A receptor agonist: F-13640; 5-HT1A receptor antagonist: WAY-
100635) were assessed on capsaicin-induced mechanical hypersensitivity, a pain behavior
involving hypersensitivity of dorsal horn neurons (central sensitization). For the 5-HT7 …
secondary to a sensitizing stimulus in mice. For this purpose, the effects of relevant ligands
(5-HT7 receptor agonists: AS-19, MSD-5a, E-55888; 5-HT7 receptor antagonists: SB-
258719, SB-269970; 5-HT1A receptor agonist: F-13640; 5-HT1A receptor antagonist: WAY-
100635) were assessed on capsaicin-induced mechanical hypersensitivity, a pain behavior
involving hypersensitivity of dorsal horn neurons (central sensitization). For the 5-HT7 …