An excitatory role for 5-HT in spinal inflammatory nociceptive transmission; state-dependent actions via dorsal horn 5-HT3 receptors in the anaesthetized rat
GM Green, J Scarth, A Dickenson - Pain, 2000 - Elsevier
The involvement of 5-HT3 receptor mediated modulation of formalin and carrageenan
induced inflammatory transmission was investigated. The effects of the selective 5-HT3
receptor antagonist ondansetron on the electrically evoked responses of dorsal horn
neurones in normal animals were compared to those following carrageenan. The effect of
pre-treatment on the formalin response was also studied. Ondansetron had no significant
effect on the electrically evoked responses of dorsal horn neurones in normal animals or …
induced inflammatory transmission was investigated. The effects of the selective 5-HT3
receptor antagonist ondansetron on the electrically evoked responses of dorsal horn
neurones in normal animals were compared to those following carrageenan. The effect of
pre-treatment on the formalin response was also studied. Ondansetron had no significant
effect on the electrically evoked responses of dorsal horn neurones in normal animals or …