Concurrent mapping of brain sites for sensitivity to the direct application of morphine and focal electrical stimulation in the production of antinociception in the rat
JC Yeung, TL Yaksh, TA Rudy - Pain, 1977 - Elsevier
The effect of morphine microinjection (5 μg/0.5 μl) and focal electrical stimulation on the
animal's response to radiant heat and noxious pinch was studied concurrently at 117 brain
loci extending from the medial thalamus caudally to the periaqueductal gray area (PAG).
Three populations of brain sites were discernible based on their responsiveness to focal
electrical stimulation and morphine microinjection in the production of antinociception: 1.(a)
sites which support stimulation-produced analgesia (SPA, n= 24), 2.(b) sites which were …
animal's response to radiant heat and noxious pinch was studied concurrently at 117 brain
loci extending from the medial thalamus caudally to the periaqueductal gray area (PAG).
Three populations of brain sites were discernible based on their responsiveness to focal
electrical stimulation and morphine microinjection in the production of antinociception: 1.(a)
sites which support stimulation-produced analgesia (SPA, n= 24), 2.(b) sites which were …