In patients with localized musculoskeletal pain, spread of pain and tenderness outside the
primarily painful area and sometimes even generalization of pain have been reported, the
latter possibly indicating a dysfunction of endogenous pain modulatory systems. The
purpose of the study was to use patients with long-term trapezius myalgia as a model to
investigate the possible influence of a localized muscle pain on somatosensory processing
in a remote pain-free area and the effect of heterotopic noxious conditioning stimulation …