BACKGROUND: Depressed mood alters the pain experience. Yet, despite its clear clinical
relevance, little is known about the cognitive and neural mechanisms underlying this
phenomenon. We tested an experimental manipulation to unravel the interaction between
depressed mood and pain. We hypothesized that dysregulation of the neural circuitry
underlying emotion regulation is the mechanism whereby pain processing is affected during
depressed mood. METHODS: Using functional magnetic resonance imaging, we compared …