Activation of proteinase-activated receptors induces itch-associated response through histamine-dependent and-independent pathways in mice
K Tsujii, T Andoh, JB Lee, Y Kuraishi - Journal of pharmacological sciences, 2008 - Elsevier
K Tsujii, T Andoh, JB Lee, Y Kuraishi
Journal of pharmacological sciences, 2008•ElsevierAbstract Proteinase-activated receptor-2 (PAR 2) participates in itch, but the role of the other
subtypes of this receptor remain unknown. To investigate this issue, scratching, an itch-
related behavior, was observed following intradermal injections of the activating peptides of
PAR 1–4 in mice. Activating peptides of PAR 1, PAR 2, and PAR 4, but not PAR 3, induced
scratching. The antihistamine terfenadine suppressed scratching elicited by activating
peptides of PAR 1 and PAR 4, but not PAR 2. These results suggest that PAR 1, PAR 2, and …
subtypes of this receptor remain unknown. To investigate this issue, scratching, an itch-
related behavior, was observed following intradermal injections of the activating peptides of
PAR 1–4 in mice. Activating peptides of PAR 1, PAR 2, and PAR 4, but not PAR 3, induced
scratching. The antihistamine terfenadine suppressed scratching elicited by activating
peptides of PAR 1 and PAR 4, but not PAR 2. These results suggest that PAR 1, PAR 2, and …
Abstract
Proteinase-activated receptor-2 (PAR2) participates in itch, but the role of the other subtypes of this receptor remain unknown. To investigate this issue, scratching, an itch-related behavior, was observed following intradermal injections of the activating peptides of PAR1–4 in mice. Activating peptides of PAR1, PAR2, and PAR4, but not PAR3, induced scratching. The antihistamine terfenadine suppressed scratching elicited by activating peptides of PAR1 and PAR4, but not PAR2. These results suggest that PAR1, PAR2, and PAR4 are involved in itch and that histamine is a cause of itch related to PAR1 and PAR4, but not PAR2.
Elsevier