Many cold sensitive peripheral neurons of the mouse do not express TRPM8 or TRPA1

C Munns, M AlQatari, M Koltzenburg - Cell calcium, 2007 - Elsevier
Neurons of the peripheral nervous system detect changes in temperature through activation
of specialised ion channels. Members of the transient receptor potential family TRPM8 and
TRPA1 are candidates for the principal transducers of cold stimuli. Using ratiometric calcium
imaging we now show that 19% of acutely dissociated mouse dorsal root (DRG) and 45% of
superior cervical ganglia (SCG) neurons responded to a brief cold stimulus. Amongst cold-
responsive DRG neurons 34±2% responded to the TRPM8 agonist menthol, 18±3% to the …