TRPM8, but not TRPA1, is required for neural and behavioral responses to acute noxious cold temperatures and cold-mimetics in vivo
WM Knowlton, A Bifolck-Fisher, DM Bautista… - Pain, 2010 - Elsevier
Somatosensory neurons detect environmental stimuli, converting external cues into neural
activity that is relayed first to second-order neurons in the spinal cord. The detection of cold
is proposed to be mediated by the ion channels TRPM8 and TRPA1. However, there is
significant debate regarding the role of each channel in cold-evoked pain, complicating their
potential as drug targets for conditions such as cold allodynia and hyperalgesia. To address
this debate, we generated mice lacking functional copies of both channels and examined …
activity that is relayed first to second-order neurons in the spinal cord. The detection of cold
is proposed to be mediated by the ion channels TRPM8 and TRPA1. However, there is
significant debate regarding the role of each channel in cold-evoked pain, complicating their
potential as drug targets for conditions such as cold allodynia and hyperalgesia. To address
this debate, we generated mice lacking functional copies of both channels and examined …