The pregnancy complications of unexplained intrauterine growth restriction and early onset
preeclampsia are thought to share a common aetiology in placental malperfusion secondary
to deficient maternal spiral artery conversion. A key question is whether the contrasting
clinical manifestations reflect different placental pathologies, or whether they are due to
altered maternal responses to a common factor derived from the placenta. Recently,
molecular evidence of protein synthesis inhibition secondary to endoplasmic reticulum …