Urinary neutrophil gelatinase-associated lipocalin (NGAL) is an early biomarker for renal tubulointerstitial injury in IgA nephropathy

H Ding, Y He, K Li, J Yang, X Li, R Lu, W Gao - Clinical Immunology, 2007 - Elsevier
Renal tubulointerstitial injury plays an important role in the development of IgA nephropathy
(IgAN), the most common form of glomerulonephritis. Few currently in use biomarkers can
sensitively detect the earliest signs of renal tubular injury, hindering our efforts to launch
preventive and therapeutic measures for this disorder in a timely manner. Neutrophil
gelatinase-associated lipocalin (NGAL) is an acute phase protein that is rapidly released
from not only neutrophils but also a variety of cell types upon inflammation and tissue injury …