The HLA-E locus is associated with age at onset and susceptibility to type 1 diabetes mellitus
AD Hodgkinson, BA Millward, AG Demaine - Human immunology, 2000 - Elsevier
Previous studies have suggested that the human leukocyte antigen (HLA) class I region may
be involved in determining the age at onset and clinical severity of type 1 diabetes. We have
investigated the frequency of polymorphisms of the nonclassical HLA class I gene, HLA-E, in
199 British Caucasian patients with type 1 diabetes and 82 healthy controls. A highly
significant increase in the frequency of the HLA-E 0101 genotype was found in the patients
compared to controls (χ2= 15.3, p< 0.00009). The frequency of the HLA-E 0101 genotype …
be involved in determining the age at onset and clinical severity of type 1 diabetes. We have
investigated the frequency of polymorphisms of the nonclassical HLA class I gene, HLA-E, in
199 British Caucasian patients with type 1 diabetes and 82 healthy controls. A highly
significant increase in the frequency of the HLA-E 0101 genotype was found in the patients
compared to controls (χ2= 15.3, p< 0.00009). The frequency of the HLA-E 0101 genotype …