[HTML][HTML] Identification of critical residues of the MyD88 death domain involved in the recruitment of downstream kinases
M Loiarro, G Gallo, N Fantò, R De Santis… - Journal of Biological …, 2009 - ASBMB
MyD88 couples the activation of the Toll-like receptors and interleukin-1 receptor
superfamily with intracellular signaling pathways. Upon ligand binding, activated receptors
recruit MyD88 via its Toll-interleukin-1 receptor domain. MyD88 then allows the recruitment
of the interleukin-1 receptor-associated kinases (IRAKs). We performed a site-directed
mutagenesis of MyD88 residues, conserved in death domains of the homologous FADD and
Pelle proteins, and analyzed the effect of the mutations on MyD88 signaling. Our studies …
superfamily with intracellular signaling pathways. Upon ligand binding, activated receptors
recruit MyD88 via its Toll-interleukin-1 receptor domain. MyD88 then allows the recruitment
of the interleukin-1 receptor-associated kinases (IRAKs). We performed a site-directed
mutagenesis of MyD88 residues, conserved in death domains of the homologous FADD and
Pelle proteins, and analyzed the effect of the mutations on MyD88 signaling. Our studies …