Multiple anticancer effects of blocking MEK-ERK signaling in hepatocellular carcinoma1
CA Wiesenauer, MT Yip-Schneider… - Journal of the …, 2004 - journals.lww.com
Background Human hepatocellular carcinoma (HCC) is associated with increased
expression and activity of mitogen-activated protein kinase (MAPK) signaling intermediates
(ie, MEK, ERK). Study design We determined the effects of MEK-ERK signaling on
proliferation, cell cycle, apoptosis, and tumorigenicity of HCC in vitro. HCC cell lines were
treated with MEK enzyme-specific inhibitors, PD098059 and U0126, and ERK1, 2
oligonucleotide antisense. Results In the HCC cells examined, MEK inhibitors blocked …
expression and activity of mitogen-activated protein kinase (MAPK) signaling intermediates
(ie, MEK, ERK). Study design We determined the effects of MEK-ERK signaling on
proliferation, cell cycle, apoptosis, and tumorigenicity of HCC in vitro. HCC cell lines were
treated with MEK enzyme-specific inhibitors, PD098059 and U0126, and ERK1, 2
oligonucleotide antisense. Results In the HCC cells examined, MEK inhibitors blocked …