[PDF][PDF] Reaching a genetic and molecular understanding of skeletal development

G Karsenty, EF Wagner - Developmental cell, 2002 - cell.com
Developmental cell, 2002cell.com
In the last ten years, we have made considerable progress in our genetic and molecular
understanding of all aspects of skeletal development, chondrogenesis, joint formation, and
osteogenesis. This review addresses the role of the principal growth factors and
transcription factors affecting these different processes and presents, in several cases, the
genetic cascade leading to cell differentiation.
Abstract
In the last ten years, we have made considerable progress in our genetic and molecular understanding of all aspects of skeletal development, chondrogenesis, joint formation, and osteogenesis. This review addresses the role of the principal growth factors and transcription factors affecting these different processes and presents, in several cases, the genetic cascade leading to cell differentiation.
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