Therapeutic role of TGF-β–neutralizing antibody in mouse cyclosporin A nephropathy: morphologic improvement associated with functional preservation
H Ling, X Li, S Jha, W Wang, L Karetskaya… - Journal of the …, 2003 - journals.lww.com
TGF-β is believed to play a central role in the development of Cyclosporin A (CsA)-induced
nephropathy. This study investigated the effects of 1D11, a murine pan-specific TGF-β–
neutralizing monoclonal antibody, in an ICR mouse model of chronic CsA nephropathy.
Mice were administered a low-salt diet (0.01% sodium) for 1 wk followed by CsA treatment
(30 mg/kg, subcutaneously, daily) for 4 wk. 1D11 was administered (2.5 mg/kg,
intraperitoneally, 3 times/wk) beginning immediately after the termination of CsA dosing and …
nephropathy. This study investigated the effects of 1D11, a murine pan-specific TGF-β–
neutralizing monoclonal antibody, in an ICR mouse model of chronic CsA nephropathy.
Mice were administered a low-salt diet (0.01% sodium) for 1 wk followed by CsA treatment
(30 mg/kg, subcutaneously, daily) for 4 wk. 1D11 was administered (2.5 mg/kg,
intraperitoneally, 3 times/wk) beginning immediately after the termination of CsA dosing and …