A revised picture of the E2F transcriptional network and RB function

O Stevaux, NJ Dyson - Current opinion in cell biology, 2002 - Elsevier
O Stevaux, NJ Dyson
Current opinion in cell biology, 2002Elsevier
New techniques have enhanced our picture of E2F regulation. These studies have shed
light on the roles played by individual E2F and retinoblastoma family members and implicate
these proteins in processes extending well beyond the G1/S transition. One thorny issue
remains: do our current molecular models of E2F and retinoblastoma action explain all of the
functions of these proteins in vivo?
New techniques have enhanced our picture of E2F regulation. These studies have shed light on the roles played by individual E2F and retinoblastoma family members and implicate these proteins in processes extending well beyond the G1/S transition. One thorny issue remains: do our current molecular models of E2F and retinoblastoma action explain all of the functions of these proteins in vivo?
Elsevier