[HTML][HTML] The collagenolytic activity of cathepsin K is unique among mammalian proteinases
P Garnero, O Borel, I Byrjalsen, M Ferreras… - Journal of Biological …, 1998 - ASBMB
Type I collagen fibers account for 90% of the organic matrix of bone. The degradation of this
collagen is a major event during bone resorption, but its mechanism is unknown. A series of
data obtained in biological models strongly suggests that the recently discovered cysteine
proteinase cathepsin K plays a key role in bone resorption. Little is known, however, about
the actual action of cathepsin K on type I collagen. Here, we show that the activity of
cathepsin K alone is sufficient to dissolve completely insoluble collagen of adult human …
collagen is a major event during bone resorption, but its mechanism is unknown. A series of
data obtained in biological models strongly suggests that the recently discovered cysteine
proteinase cathepsin K plays a key role in bone resorption. Little is known, however, about
the actual action of cathepsin K on type I collagen. Here, we show that the activity of
cathepsin K alone is sufficient to dissolve completely insoluble collagen of adult human …