Human and mouse proteases: a comparative genomic approach

XS Puente, LM Sánchez, CM Overall… - Nature Reviews …, 2003 - nature.com
XS Puente, LM Sánchez, CM Overall, C López-Otín
Nature Reviews Genetics, 2003nature.com
The availability of the human and mouse genome sequences has allowed the identification
and comparison of their respective degradomes—the complete repertoire of proteases that
are produced by these organisms. Because of the essential roles of proteolytic enzymes in
the control of cell behaviour, survival and death, degradome analysis provides a useful
framework for the global exploration of these protease-mediated functions in normal and
pathological conditions.
Abstract
The availability of the human and mouse genome sequences has allowed the identification and comparison of their respective degradomes — the complete repertoire of proteases that are produced by these organisms. Because of the essential roles of proteolytic enzymes in the control of cell behaviour, survival and death, degradome analysis provides a useful framework for the global exploration of these protease-mediated functions in normal and pathological conditions.
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