[HTML][HTML] p53 suppresses the c-Myb-induced activation of heat shock transcription factor 3
J Tanikawa, E Ichikawa-Iwata, C Kanei-Ishii… - Journal of Biological …, 2000 - ASBMB
Expression of heat shock proteins (HSPs) is controlled by heat shock transcription factors
(HSFs). Vertebrates express multiple HSFs whose activities may be regulated by distinct
signals. HSF3 is specifically activated in unstressed proliferating cells by direct binding to
the c-myb proto-oncogene product (c-Myb), which plays an important role in cellular
proliferation. This suggests that the c-Myb-induced HSF3 activation may contribute to the
growth-regulated expression of HSPs. Here we report that the p53 tumor suppressor protein …
(HSFs). Vertebrates express multiple HSFs whose activities may be regulated by distinct
signals. HSF3 is specifically activated in unstressed proliferating cells by direct binding to
the c-myb proto-oncogene product (c-Myb), which plays an important role in cellular
proliferation. This suggests that the c-Myb-induced HSF3 activation may contribute to the
growth-regulated expression of HSPs. Here we report that the p53 tumor suppressor protein …