Thymic stromal lymphopoietin in normal and pathogenic T cell development and function
SF Ziegler, YJ Liu - Nature immunology, 2006 - nature.com
SF Ziegler, YJ Liu
Nature immunology, 2006•nature.comThymic stromal lymphopoietin, a four helix–bundle cytokine, is expressed mainly by barrier
epithelial cells and is a potent activator of several cell types, particularly myeloid dendritic
cells. TSLP influences the outcome of interactions between dendritic cells and CD4+
thymocytes and T cells in many situations, such as the regulation of the positive selection of
regulatory T cells, maintenance of peripheral CD4+ T cell homeostasis and induction of
CD4+ T cell–mediated allergic inflammation.
epithelial cells and is a potent activator of several cell types, particularly myeloid dendritic
cells. TSLP influences the outcome of interactions between dendritic cells and CD4+
thymocytes and T cells in many situations, such as the regulation of the positive selection of
regulatory T cells, maintenance of peripheral CD4+ T cell homeostasis and induction of
CD4+ T cell–mediated allergic inflammation.
Thymic stromal lymphopoietin, a four helix–bundle cytokine, is expressed mainly by barrier epithelial cells and is a potent activator of several cell types, particularly myeloid dendritic cells. TSLP influences the outcome of interactions between dendritic cells and CD4+ thymocytes and T cells in many situations, such as the regulation of the positive selection of regulatory T cells, maintenance of peripheral CD4+ T cell homeostasis and induction of CD4+ T cell–mediated allergic inflammation.
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