Mechanisms of evasion of neutrophil killing by Anaplasma phagocytophilum
JA Carlyon, E Fikrig - Current opinion in hematology, 2006 - journals.lww.com
JA Carlyon, E Fikrig
Current opinion in hematology, 2006•journals.lww.comA. phagocytophilum combats neutrophil oxidative killing by scavenging O 2−, inhibiting
NADPH oxidase assembly on its vacuolar membrane, and modifying promoter activity for a
key NADPH oxidase component, gp91 phox. Uptake of this unique pathogen fails to induce
neutrophil apoptosis. Furthermore, A. phagocytophilum extends the life of its otherwise short-
lived host cell by dysregulating neutrophil gene expression and molecular machinery to
potentially maximize its survival and dissemination within its mammalian host.
NADPH oxidase assembly on its vacuolar membrane, and modifying promoter activity for a
key NADPH oxidase component, gp91 phox. Uptake of this unique pathogen fails to induce
neutrophil apoptosis. Furthermore, A. phagocytophilum extends the life of its otherwise short-
lived host cell by dysregulating neutrophil gene expression and molecular machinery to
potentially maximize its survival and dissemination within its mammalian host.
Summary
A. phagocytophilum combats neutrophil oxidative killing by scavenging O 2−, inhibiting NADPH oxidase assembly on its vacuolar membrane, and modifying promoter activity for a key NADPH oxidase component, gp91 phox. Uptake of this unique pathogen fails to induce neutrophil apoptosis. Furthermore, A. phagocytophilum extends the life of its otherwise short-lived host cell by dysregulating neutrophil gene expression and molecular machinery to potentially maximize its survival and dissemination within its mammalian host.
Lippincott Williams & Wilkins