[HTML][HTML] Cystic fibrosis airway epithelial Ca2+ i signaling: the mechanism for the larger agonist-mediated Ca2+ i signals in human cystic fibrosis airway epithelia

CMP Ribeiro, AM Paradiso, MA Carew… - Journal of Biological …, 2005 - ASBMB
In cystic fibrosis (CF) airways, abnormal epithelial ion transport likely initiates mucus stasis,
resulting in persistent airway infections and chronic inflammation. Mucus clearance is
regulated, in part, by activation of apical membrane receptors coupled to intracellular
calcium (Ca 2+ i) mobilization. We have shown that Ca 2+ i signals resulting from apical
purinoceptor (P2Y 2-R) activation are increased in CF compared with normal human airway
epithelia. The present study addressed the mechanism for the larger apical P2Y 2-R …