Cytosolic Ca2+ responses to sub-picomolar and nanomolar PACAP in pancreatic β-cells are mediated by VPAC2 and PAC1 receptors
H Yamada, M Watanabe, T Yada - Regulatory peptides, 2004 - Elsevier
Pituitary adenylate cyclase-activating polypeptide (PACAP) potentiates glucose-induced
insulin release and increases cytosolic Ca2+ concentration ([Ca2+] i) in islet β-cells in a
concentration-dependent manner with two peaks at 10− 13 and 10− 9 M. PAC1 receptor
(PAC1-R) and VPAC2 receptor (VPAC2-R) are expressed in pancreatic β-cells and thought
to be involved in insulin release. We aimed to determine the receptor types involved in the
[Ca2+] i responses to 10− 13 and 10− 9 M PACAP. We measured [Ca2+] i in β-cells and …
insulin release and increases cytosolic Ca2+ concentration ([Ca2+] i) in islet β-cells in a
concentration-dependent manner with two peaks at 10− 13 and 10− 9 M. PAC1 receptor
(PAC1-R) and VPAC2 receptor (VPAC2-R) are expressed in pancreatic β-cells and thought
to be involved in insulin release. We aimed to determine the receptor types involved in the
[Ca2+] i responses to 10− 13 and 10− 9 M PACAP. We measured [Ca2+] i in β-cells and …