[HTML][HTML] The mood stabilizer valproic acid activates mitogen-activated protein kinases and promotes neurite growth
PX Yuan, LD Huang, YM Jiang, JS Gutkind… - Journal of Biological …, 2001 - ASBMB
The mood-stabilizing agents lithium and valproic acid (VPA) increase DNA binding activity
and transactivation activity of AP-1 transcription factors, as well as the expression of genes
regulated by AP-1, in cultured cells and brain regions involved in mood regulation. In the
present study, we found that VPA activated extracellular signal-regulated kinase (ERK), a
kinase known to regulate AP-1 function and utilized by neurotrophins to mediate their
diverse effects, including neuronal differentiation, neuronal survival, long term …
and transactivation activity of AP-1 transcription factors, as well as the expression of genes
regulated by AP-1, in cultured cells and brain regions involved in mood regulation. In the
present study, we found that VPA activated extracellular signal-regulated kinase (ERK), a
kinase known to regulate AP-1 function and utilized by neurotrophins to mediate their
diverse effects, including neuronal differentiation, neuronal survival, long term …