The published DNA sequence of human cytomegalovirus strain AD169 lacks 929 base pairs affecting genes UL42 and UL43
DJ Dargan, FE Jamieson, J MacLean, A Dolan… - Journal of …, 1997 - Am Soc Microbiol
DJ Dargan, FE Jamieson, J MacLean, A Dolan, C Addison, DJ McGeoch
Journal of virology, 1997•Am Soc MicrobiolCompared with the published DNA sequence (MS Chee, et al. Curr. Top. Microbiol.
Immunol. 154: 125-170, 1990), most isolates of human cytomegalovirus strain AD169
contain an additional 929 bp after nucleotide 54612. This results in a changed reading
frame for the 5'-terminal 50 codons of gene UL42 and expansion of gene UL43 (a US22
family member) from 187 (3'-truncated) to 423 (full-length) codons. The UL42 and UL43
gene products are nonessential for growth in culture.
Immunol. 154: 125-170, 1990), most isolates of human cytomegalovirus strain AD169
contain an additional 929 bp after nucleotide 54612. This results in a changed reading
frame for the 5'-terminal 50 codons of gene UL42 and expansion of gene UL43 (a US22
family member) from 187 (3'-truncated) to 423 (full-length) codons. The UL42 and UL43
gene products are nonessential for growth in culture.
Compared with the published DNA sequence (M. S. Chee, et al. Curr. Top. Microbiol. Immunol. 154:125-170, 1990), most isolates of human cytomegalovirus strain AD169 contain an additional 929 bp after nucleotide 54612. This results in a changed reading frame for the 5'-terminal 50 codons of gene UL42 and expansion of gene UL43 (a US22 family member) from 187 (3'-truncated) to 423 (full-length) codons. The UL42 and UL43 gene products are nonessential for growth in culture.
American Society for Microbiology