Lung granulomas from Mycobacterium tuberculosis/HIV-1 co-infected patients display decreased in situ TNF production

ALL de Noronha, A Bafica, L Nogueira, A Barral… - … -Research and Practice, 2008 - Elsevier
Tuberculosis/HIV-1 co-infection is responsible for thousands of deaths each year, and
previous studies have reported that co-infected individuals display major morphological
alterations in tissue granulomas. The purpose of this study was to evaluate
immunohistopathological characteristics in lung tissues from pulmonary TB/HIV-1-co-
infected individuals. Following autopsy, tuberculosis-positive HIV-1-negative cases
displayed granulomas with normal architecture, mainly composed of a mononuclear infiltrate …