To determine whether decreased regulatory T cell activity contributes to the pathogenesis of
recurrent experimental autoimmune uveitis (EAU), we compared the immunoregulatory
activity of CD8+ CD45RClow T cells isolated from rats that had recovered from acute EAU
with those from rats with the progressive, recurrent disease. Our results showed that CD8+
CD45RClow T cells isolated from the recovered rats showed suppressive activity in vitro,
whereas those from rats with progressive, recurrent EAU do not. Depletion of CD8+ …