Endotoxin induced uveitis in the mouse: susceptibility and genetic control
Q Li, B Peng, SM Whitcup, SU Jang, CC Chan - Experimental eye research, 1995 - Elsevier
Endotoxin induced uveitis in the mouse provides a useful animal model for acute anterior
uveitis in humans. We have investigated the susceptibility of endotoxin-induced uveitis
among various mouse strains, and have examined the relationship between genetic
background and the resultant inflammatory response to endotoxin. We studied ten strains
with differing major histocompatibility-2 genes, lipopolysaccharide response gene, and
strains with mast cell depletion and its sham control. Anterior uveitis was induced by …
uveitis in humans. We have investigated the susceptibility of endotoxin-induced uveitis
among various mouse strains, and have examined the relationship between genetic
background and the resultant inflammatory response to endotoxin. We studied ten strains
with differing major histocompatibility-2 genes, lipopolysaccharide response gene, and
strains with mast cell depletion and its sham control. Anterior uveitis was induced by …