The fate of the phagosome: conversion to'age pigment'and impact in human retinal pigment epithelium.
L Feeney-Burns, GE Eldred - Transactions of the ophthalmological …, 1983 - europepmc.org
L Feeney-Burns, GE Eldred
Transactions of the ophthalmological societies of the United Kingdom, 1983•europepmc.orgPhagosomes are converted to phagolysosomes and then to residual bodies (also known as
lipofuscin granules or age pigment). Lipofuscin granules of retinal pigment epithelial (RPE)
cells of single human eyes were isolated and analysed for enzyme content and fluorescence
spectra. The granules are low in lysosomal enzymes and they fluoresce yellow-gold. Thin
layer chromatography reveals several separable constituents. Lipofuscin granules
accumulate with age, the largest increase occurring after the first decade of life in humans …
lipofuscin granules or age pigment). Lipofuscin granules of retinal pigment epithelial (RPE)
cells of single human eyes were isolated and analysed for enzyme content and fluorescence
spectra. The granules are low in lysosomal enzymes and they fluoresce yellow-gold. Thin
layer chromatography reveals several separable constituents. Lipofuscin granules
accumulate with age, the largest increase occurring after the first decade of life in humans …
Phagosomes are converted to phagolysosomes and then to residual bodies (also known as lipofuscin granules or age pigment). Lipofuscin granules of retinal pigment epithelial (RPE) cells of single human eyes were isolated and analysed for enzyme content and fluorescence spectra. The granules are low in lysosomal enzymes and they fluoresce yellow-gold. Thin layer chromatography reveals several separable constituents. Lipofuscin granules accumulate with age, the largest increase occurring after the first decade of life in humans. Macular RPE cells accumulate granules more than non-macular cells.
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