Ranibizumab for predominantly classic neovascular age-related macular degeneration: subgroup analysis of first-year ANCHOR results
American journal of ophthalmology, 2007•Elsevier
PURPOSE: Subgroup data from a pivotal phase 3 study comparing ranibizumab
(LUCENTIS) with verteporfin (VISUDYNE) photodynamic therapy (PDT) in patients with
predominantly classic choroidal neovascularization (CNV) secondary to age-related
macular degeneration (AMD) were retrospectively analyzed to identify patient and disease
characteristics that may predict visual acuity (VA) treatment outcomes. DESIGN:
Retrospective subgroup analysis of 12-month data from the ANCHOR study. METHODS …
(LUCENTIS) with verteporfin (VISUDYNE) photodynamic therapy (PDT) in patients with
predominantly classic choroidal neovascularization (CNV) secondary to age-related
macular degeneration (AMD) were retrospectively analyzed to identify patient and disease
characteristics that may predict visual acuity (VA) treatment outcomes. DESIGN:
Retrospective subgroup analysis of 12-month data from the ANCHOR study. METHODS …
PURPOSE
Subgroup data from a pivotal phase 3 study comparing ranibizumab (LUCENTIS) with verteporfin (VISUDYNE) photodynamic therapy (PDT) in patients with predominantly classic choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD) were retrospectively analyzed to identify patient and disease characteristics that may predict visual acuity (VA) treatment outcomes.
DESIGN
Retrospective subgroup analysis of 12-month data from the ANCHOR study.
METHODS
Univariate analyses were performed to assess VA outcomes across subgroups based on patients’ gender and baseline age, VA score, CNV lesion size, CNV lesion type, and duration of neovascular AMD, followed by multivariate analyses to identify predictors of the VA score change from baseline at 12 months. main outcome measures: Proportion of patients losing <15 letters and proportion gaining ≥15 letters from baseline VA; mean change from baseline VA.
RESULTS
On average, all subgroups of ranibizumab-treated patients did better than PDT patients for all three VA outcome measures. In the multivariate analysis, lower baseline VA score, smaller baseline CNV lesion size, and younger baseline age were associated with greater gain of letters with ranibizumab treatment and less loss of letters with PDT.
CONCLUSIONS
Subgroup analysis of 12-month data from the ANCHOR study showed ranibizumab to be superior to PDT in all subgroups evaluated, and was consistent with the subgroup analysis of 24-month data from the other pivotal phase 3 study of ranibizumab (MARINA) in showing that the most important predictors of VA outcomes were, in decreasing order of impact, the patient’s baseline VA score, CNV lesion size, and age.
Elsevier