The purpose of this study was to examine the localization and relative levels of vascular
endothelial growth factor (VEGF; an angiogenic factor) and pigment epithelium-derived
factor (PEDF; an antiangiogenic factor) in aged human choroid and to determine if the
localization or their relative levels changed in age-related macular degeneration (AMD).
Ocular tissues were obtained from eight aged control donors (age range, 75–86 years;
mean age, 79.8 years) with no evidence or history of chorioretinal disease and from 12 …