Genome-wide association studies herald a new era of rapid discoveries in inflammatory bowel disease research
RH Duerr - Gastroenterology, 2007 - gastrojournal.org
The pathogenesis of the inflammatory bowel diseases (IBD), namely, Crohn's disease (CD)
and ulcerative colitis (UC), involves a complex interplay of genetic, environmental, and
immunologic factors. A large body of evidence supports the hypothesis that ubiquitous,
commensal intestinal bacteria trigger an inappropriate, overactive, and ongoing mucosal
immune response that mediates intestinal tissue damage in genetically susceptible
individuals. 1 Early attempts to identify IBD genes focused primarily on functional …
and ulcerative colitis (UC), involves a complex interplay of genetic, environmental, and
immunologic factors. A large body of evidence supports the hypothesis that ubiquitous,
commensal intestinal bacteria trigger an inappropriate, overactive, and ongoing mucosal
immune response that mediates intestinal tissue damage in genetically susceptible
individuals. 1 Early attempts to identify IBD genes focused primarily on functional …