[HTML][HTML] Suppressed disassembly of autolyzing p94/CAPN3 by N2A connectin/titin in a genetic reporter system
Y Ono, F Torii, K Ojima, N Doi, K Yoshioka… - Journal of Biological …, 2006 - ASBMB
p94/calpain 3 is a skeletal muscle-specific member of the Ca 2+-regulated cytosolic cysteine
protease family, the calpains. Defective p94 protease activity originating from gene
mutations causes a muscular dystrophy called calpainopathy, indicating the indispensability
of p94 for muscle survival. Because of the existence of the p94-specific regions IS1 and IS2,
p94 undergoes very rapid and exhaustive autolysis. To elucidate the physiological
relevance of this unique activity, the autolytic profiles of p94 and the effect of the p94 binding …
protease family, the calpains. Defective p94 protease activity originating from gene
mutations causes a muscular dystrophy called calpainopathy, indicating the indispensability
of p94 for muscle survival. Because of the existence of the p94-specific regions IS1 and IS2,
p94 undergoes very rapid and exhaustive autolysis. To elucidate the physiological
relevance of this unique activity, the autolytic profiles of p94 and the effect of the p94 binding …