The giant protein titin: a major player in myocardial mechanics, signaling, and disease

HL Granzier, S Labeit - Circulation research, 2004 - Am Heart Assoc
HL Granzier, S Labeit
Circulation research, 2004Am Heart Assoc
The sarcomere contains, in addition to thin and thick filaments, a filament composed of the
giant protein titin (also known as connectin). Titin molecules anchor in the Z-disc and extend
to the M-line region of the sarcomere. The majority of titin's I-band region functions as a
molecular spring. This spring maintains the precise structural arrangement of thick and thin
filaments, and gives rise to passive muscle stiffness; an important determinant of diastolic
filling. Earlier work on titin has been reviewed before. In this study, our main focus is on …
The sarcomere contains, in addition to thin and thick filaments, a filament composed of the giant protein titin (also known as connectin). Titin molecules anchor in the Z-disc and extend to the M-line region of the sarcomere. The majority of titin’s I-band region functions as a molecular spring. This spring maintains the precise structural arrangement of thick and thin filaments, and gives rise to passive muscle stiffness; an important determinant of diastolic filling. Earlier work on titin has been reviewed before. In this study, our main focus is on recent findings vis-à-vis titin’s molecular spring segments in cardiac titins, including the discovery of fetal cardiac isoforms with novel spring elements. We also discuss new insights regarding the role of titin as a biomechanical sensor and signaling molecule. We will end with focusing on the rapidly growing knowledge regarding titinopathies.
Am Heart Assoc